The Solutrean culture is temporally intermediate between the Gravettian and the Magdalenian (or the Badegoulian) cultures, and is found in southwestern and western Europe, which are considered to have been climatic refugia for human populations during the LGM25,26. 12 Data Science YouTube Channels by Women to Follow Individuals with libraries showing signs of contamination were further tested using PMD-filtered bam files. In sum, we describe the formation and interaction between the Oberkassel and Sidelkino clusters, the two main hunter-gatherer ancestries present in Europe from 14ka onwards. Tina Huang - Senior Tax Analyst - Lion | LinkedIn Nature 524, 216219 (2015). Her first stepping stone into data science was being a research assistant in Bioinformatics. In particular, the 13ka Pradis 1 individual from northeastern Italy represents the most basal lineage compared to all other Epigravettian-associated individuals, including the older Tagliente 2 and Villabruna genomes from northern Italy (group 1). Palaeogenomics of Upper Palaeolithic to Neolithic European hunter-gatherers. CAS Tina Huang - YouTube Tina is excellent when it comes to getting overall data science career advice. Author pages are created from data sourced from our academic publisher partnerships and public sources. All Rights Reserved. In addition to this general data science content, Tina teaches SQL . J. Archaeol. The competition is based on a pretty strict data set thats been collected by the Stanford Computer Science department. Jnsson, H., Ginolhac, A., Schubert, M., Johnson, P. L. F. & Orlando, L. MapDamage2.0: fast approximate Bayesian estimates of ancient DNA damage parameters. Google Scholar. This may have prompted people from the south to expand their habitat. EAGER: efficient ancient genome reconstruction. Tina Huang is a prominent data scientist, previously working at a FAANG company, and has been an active YouTuber, creating data science content for nearly a decade. Ecologizr. Curr. Nucleic Acids Res. All remains were sampled with the approval of the institutions responsible for the analysis of archaeological material. Libraries were quantified using the IS7 and IS8 primers59 in a quantification assay using a DyNAmo SYBR Green qPCR Kit (Thermo Fisher Scientific) on the LightCycler 480 (Roche). The mitochondrial capture sequencing reads were cleaned by AdapterRemoval 2.2.0 to remove the adapters and reads with lengths below 30bp. Her YouTube channel offers tips on productivity hacks, resume evaluations, data science employment, and more. In general, the whole point of data warehousing is to get the data from your source to your target. 5, 820825 (2021). Ice Age survivors -- ScienceDaily Shes the founder of Coding Black Females, a nonprofit with the aim to provide opportunities for Black female developers to develop themselves, meet familiar faces, network, receive support, and build relationships through having regular meetups., Check out the Coding Black Females website. Her YouTube channel advises data science jobs, self-study, boosting productivity, resume reviews, etc. Cassidy, L. M. et al. We identify a genetic ancestry profile in individuals associated with Upper Palaeolithic Gravettian assemblages from western Europe that is distinct from contemporaneous groups related to this archaeological culture in central and southern Europe4, but resembles that of preceding individuals associated with the Aurignacian culture. Twelve-month follow-up after hospitalization for SARS-COV-2: physiology USA 111, 22292234 (2014). Interviewed Taiwanese designers and analyzed the interview data. Subsequently, I worked in bioinformatics for a year and then did my Master's in computer science (MCIT) at the University of Pennsylvania. Natl Acad. Her main topic is AI, exploring how it works and, most interestingly, how we increasingly interact with it in the world. 272273, 354361 (2012). Moreover, we reveal a north-to-south decrease in genetic diversity among the Epigravettian-associated groups, with the highest PMR and heterozygosity values found in northern Italian individuals (group 1), intermediate in western and central Italian individuals (group 2) and the lowest in Sicilian individuals (group 3) (Fig. The Sidelkino ancestry also emerged around 14ka with its first direct evidence in eastern Europe43 dated to 13ka. SQL for Data Science Interviews . Olalde, I. et al. Huang, Y. assembled archaeological material, descriptions and interpretations. Genetics 192, 10651093 (2012). Biol. & Meyer, M. Extraction of highly degraded DNA from ancient bones, teeth and sediments for high-throughput sequencing. Initial Upper Palaeolithic humans in Europe had recent Neanderthal ancestry, A genomic Neolithic time transect of hunter-farmer admixture in central Poland, Palaeo-Eskimo genetic ancestry and the peopling of Chukotka and North America, A genetic history of the pre-contact Caribbean, Ancient genomes from the last three millennia support multiple human dispersals into Wallacea, Ancient DNA reveals admixture history and endogamy in the prehistoric Aegean, A 23,000-year-old southern Iberian individual links human groups that lived in Western Europe before and after the Last Glacial Maximum, Genetic history from the Middle Neolithic to present on the Mediterranean island of Sardinia, Ancient DNA from mastics solidifies connection between material culture and genetics of mesolithic huntergatherers in Scandinavia, https://github.com/stschiff/sequenceTools, https://reich.hms.harvard.edu/allen-ancient-dna-resource-aadr-downloadable-genotypes-present-day-and-ancient-dna-data, https://edmond.mpdl.mpg.de/dataset.xhtml?persistentId=doi:10.17617/3.Y1KJMF, https://haproh.readthedocs.io/en/latest/hapROH_with_contamination.html, https://doi.org/10.1007/978-94-017-7206-8_6, https://doi.org/10.1038/s41559-023-01987-0. Error bars show 1s.e.m. 8). BMC Bioinformatics 15, 356 (2014). Mateja Hajdinjak, Fabrizio Mafessoni, Svante Pbo, D. M. Fernandes, D. Strapagiel, R. Pinhasi, Pavel Flegontov, N. Ezgi Altnk, Stephan Schiffels, Daniel M. Fernandes, Kendra A. Sirak, David Reich, Sandra Oliveira, Kathrin Ngele, Mark Stoneking, Eirini Skourtanioti, Harald Ringbauer, Philipp W. Stockhammer, Vanessa Villalba-Mouco, Marieke S. van de Loosdrecht, Wolfgang Haak, Joseph H. Marcus, Cosimo Posth, John Novembre, Natalija Kashuba, Emrah Krdk, Anders Gtherstrm, Nature Piezonka, H. et al. The suspension was then centrifuged and transferred into a binding buffer as previously described56. @hellotinah. I hold a Bachelor's degree at the University of Toronto where I studied pharmacology. PubMed She has been working for the data sciences industry since 2014. For the SNP associated with light eye colour (HERC2/OCA2 (rs12913832)), individuals from the Villabruna cluster,Oberkasselcluster, Baltic HG and SHG groups show high frequencies of the derived allele (>90%), which is responsible for the green or blue eye phenotype, whereas Sidelkinocluster, Ukraine HG and Iron Gates HG groups show low occurrence of this allele (1025%). Quat. Christina Yu-Ting Wang - Design Team Lead - TomTom | LinkedIn Amina is a software engineer, who is also an accessibility advocate and content creator. 724703 and no. Fifth, the Oberkassel ancestry in western and central Europe and the Sidelkino ancestry in eastern Europe remained largely isolated for almost 6,000 years until genetic interactions were first observedaround 8ka in northeastern Germany, possibly associated with cultural exchanges along the Baltics49 and around 7.5ka in the upper Volga region, possibly linked to the spread of pottery in the region50. Max Planck Institute for Evolutionary Anthropology. This plot reveals the presence of three distinct groupings: (1) a pre-40ka group with individuals from the UstIshim, Bacho Kiro, Zlat k and Petera cu Oase sites, (2) a Vstonice cluster including Gravettian-associated individuals from centraleastern and southern European sites (Doln Vstonice, Pavlov, Krems-Wachtberg, Paglicci and Ostuni), and (3) a Fournol cluster(hereafter, Fournol cluster or ancestry) comprising Gravettian-associated individuals from western and southwestern European sites (Ormesson, La Rochette, Fournol and two Seriny cave sites (Mollet III and Reclau Viver)). W jednej z historii misiaczki za rad pewnej wydry zamieszkuj w tajemniczym . In practice, we use machine learning in different conjunctures. The PCA was calculated with 1379 individuals from 87 western Eurasian modern populations on the 1240k_HO dataset, which was intersected between the 1240k and Human Origins datasets (Supplementary Data 1.K). Posth, C., Yu, H., Ghalichi, A. et al. Article 4 Admixture graph modelling of pre-34 ka hunter-gatherer lineages. Genetic sexing revealed 78 maleindividuals and 38 femaleindividuals (Supplementary Fig. B. et al. You'll likely won't meet her on a day to day basis, but she's always lurking in the Discord and following everybody's progress (not . If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Int. Zool. In no time, she established herself as one of the favorite vloggers of the data community. Nature (Nature) Colour legend is shown in (e). Dabney, J. et al. This course will help you build a deliberate strategy when participating in a data scientist job interview involving SQL. "We find that individuals associated with a later culture, the Epigravettian, are genetically distinct from the area's previous inhabitants," says co-author He Yu. A.G.-O. ADS Science 328, 710722 (2010). People with a new gene pool settled in these areas, instead. Nature 582, 384388 (2020). These European regions, therefore, constitute climatic refugia where human populations survived during the LGM. 211 and Supplementary Table 1). To summarize, our results highlight a genetic turnover in the Italian peninsula of the Gravettian-associated Vstonice cluster by the Epigravettian-associated Villabruna cluster that might correlate with discontinuities observed in the archaeological record31. Our analyses demonstrate that the Fournol cluster is a better source for Magdalenian-associated genomes than Goyet Q116-1. From at least 14,000 years ago, an ancestry related to this culture spread from the south across the rest of Europe, largely replacing the Magdalenian-associated gene pool. 8). We love meeting interesting people and making new friends. Late Pleistocene human genome suggests a local origin for the first farmers of central Anatolia. In this video @Tina Huang and I go through 5 subscriber submitted resumes and review them. The grouping of Epigravettian-associated populations is shown with the same colour in a. Nat. Tina Huang - Instructor | 365 Data Science The Kostenki (and Sunghir group) ancestry contributed to the previously described Vstonice cluster represented by Gravettian-associated individuals from central-eastern and southern Europe4. 8 Data Science Influencers on Youtube to Subscribe to Sci. The inferred pattern of short ROH (48 cM, visualized in blue) being common is in stark contrast to most later farmer populations, where the majority of individuals have no short ROH whatsoever (see101), and evidences small effective population sizes across West Eurasian hunter-gatherer groups. Biol. This affinity is even stronger towards Epigravettian-associated individuals from western and central Italy and Sicily (group 2 and group 3, respectively) than to those from northern Italy (group 1) (Supplementary Data 2.F). It encourages me to go out and re-learn SQL and excites me for the mock interviews to come. Save my name, email, and website in this browser for the next time I comment. Modern humans have populated Europe for more than 45,000 years1,2. Double-stranded DNA libraries were built from 25l of DNA extract, without the presence of uracil DNA glycosylase (ds_nonUDG) or in the presence of uracil DNA glycosylase (ds_halfUDG), following a double-stranded UDG-half library preparation to reduce, but not eliminate, the amount of deamination-induced damage towards the ends of ancient DNA (aDNA) fragments58. Find contact's direct phone number, email address, work history, and more. Front. Li, H. et al. Gonzlez-Fortes, G. et al. I Agree, Brandwatch Bulletin #41: 7 Women in Tech You ShouldKnow. Check it out! Palaeogenomics of Upper Palaeolithic to Neolithic European hunter Roebroeks, W., Mussi, M., Svoboda, J. Sci. Dismiss. Interactions between people from central and eastern Europe can only be detected again from 8,000 years ago. The research team describes a large-scale genetic replacement that may have been caused, in part, by climatic changes that forced people to migrate: "At that time, the climate warmed up quickly and considerably and forests spread across the European continent. Karmin, M. et al. 27 and 28). Genome sequence of a 45,000-year-old modern human from western Siberia. Tina is proud she taught herself SQL from scratch in 11 days to pass her FAANG SQL interview. Genetic analyses of western European individuals associated with the preceding Badegoulian culture might provide clues on the processes that led to the formation of the GoyetQ2 cluster. Sikora, M. et al. 12, 5425 (2021). The ancient human specimens analysed in this work derive from multiple scientific collaborations. Tina Huang is one of the top three students to show up to compete. For individual heterozygosity calculation, we also called pseudo-diploid genotypes from each library, using pileupCaller 1.4.0.3 under random diploid calling mode and the same strategy for different types of libraries as pseudo-haploid genotype calling. Midzy nami, misiaczkami: Misio Teddi (27) - serial animowany Damgaard, P. et al. In the meantime, to ensure continued support, we are displaying the site without styles Extended Data Fig. Big Data, Data Mining, and Machine Learning (Jared Dean) . After 2 washing steps using the manufacturers wash buffer, DNA was eluted in TET (10mM Tris, 1mM EDTA and 0.05% Tween) in two steps for a final volume of 100l. By contrast, the Goyet Q116-1 genetic profile gave rise to the newly described Fournol cluster identified in Gravettian-associated individuals from western and southwestern Europe. Modern humans began to spread across Eurasia around 45,000 years ago but previous research showed that the first modern humans that arrived in Europe did not contribute to later populations. This provides further support for the model with no long-term decline of genome-wide Neanderthal ancestry in modern humans following their introgression18. Sign up below if you'd like to join a growing community that is enthusiastic about learning and improving their lives. Tina Huang, a former engineer at Apple, Google, and Twitter, explains why she started API management startup Transposit. The f4-statistics were calculated by qpDstat 755 with parameter f4 mode: YES, with the Mbuti.DG population from Africa used as outgroup in all f-statistics analyses. Tina Llorca CPA, CWP, CEPP, CIS, MDRT'S Post - in.linkedin.com The first horse herders and the impact of early Bronze Age steppe expansions into Asia. Sci. Youth Vaping_ An Analysis of an Epidemic.pdf - Georgia Using Y-chromosome capture enrichment to resolve haplogroup H2 shows new evidence for a two-path Neolithic expansion to Western Europe. Lipson, M. et al. www.sciencedaily.com/releases/2023/03/230301120846.htm (accessed March 4, 2023). Notes 9, 88 (2016). F4-statistics also show that the approximately8.2ka Yuzhniy Oleniy Ostrov group from Karelia in western Russia formed by 19 genomes has comparable or lower affinity to Villabruna ancestry than all the other EHG groups (Supplementary Data 2.K). Mittnik, A. et al. Mol. The version used for this work is archived at https://edmond.mpdl.mpg.de/dataset.xhtml?persistentId=doi:10.17617/3.Y1KJMF. Lazaridis, I. et al. In addition to her rich experience, including bioinformatics cancer research at OICR, Tina is a popular YouTuber with over 60K subscribers. Nat. 40,000-year-old individual from Asia provides insight into early population structure in Eurasia. Learn with a sense of purpose. Created by DataSciencePR. Then we combined our newly generated genotypes with published genotypes from ancient and modern individuals from AADR v42.4 (Allen Ancient DNA Resource (https://reich.hms.harvard.edu/allen-ancient-dna-resource-aadr-downloadable-genotypes-present-day-and-ancient-dna-data) version 42.4) for downstream analysis1,4,7,14,16,23,36,37,38,39,40,42,43,45,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94. After the LGM, a genetic component distantly linked to the Goyet Q116-1 individual from Belgiumdated to 35 kanamed GoyetQ2 ancestry(hereafter, GoyetQ2 cluster or ancestry)reappeared in individuals from southwestern and central Europe associated with the Magdalenian culture (1914ka from Iberia to eastern Europe across central Europe) and in an admixed form in subsequent Final Palaeolithic and Mesolithic hunter-gatherers4,14, but the geographic extension of this ancestry is still unclear. Grizz, Panda i Lodomir maj rne charaktery, ale pomimo odmiennoci potrafi wspdziaa i wspiera si w kopotach. She was not prepared for the complexity of a typical programming language. Top 10 Data Science Influencers to Follow on YouTube in 2023 Sci. Moreover, none of the Epigravettian-associated individuals have more affinity to southern European than to central-eastern European Gravettian-associated groups, as shown by f4(Mbuti, Epigravettian-associated individual/group; Vstonice, Paglicci 12) that is consistent with 0 (Supplementary Data 2.G). Article Branch labels show unique drift lengths; black dots refer to individuals with newly generated data and white dots refer topreviously published genomes;the position of each node does not imply the location where the split took place. Its the complexity of product development, with all of its moving parts, that makes data immensely powerful. 46, 6584 (2020). Open access funding provided by Max Planck Society. EY. The population history of northeastern Siberia since the Pleistocene. This secondary analysis of an ongoing adaptive platform trial examines the effect of multiple interventions for critically ill adults with COVID-19 on longer-term outcomes. Tina has 11 jobs listed on their profile. Details of the modelling are provided in Supplementary Data 3.C. Get the most important science stories of the day, free in your inbox. Shes the author of the popular Data Science: The Complete Guide and the creator of the popular Data Science Cookbook. She was also one of the founders of the Stanford Data Science Society. This year they plan on seeing a total of 1,280 entries. The PCA was carried out by smartpca in EIGENSOFT 6.0.1102, with modern individuals used for calculation and all the ancient individuals projected on the calculated PCs. Previously, she has interned at Goldman Sachs where she used Python and Scala to implement machine learning techniques for automated anomaly detection. Survival of Late Pleistocene hunter-gatherer ancestry in the Iberian Peninsula. Its no surprise that she was selected for the Code Cup, a yearly event where students from all over the world compete in coding challenges. Biotechniques 59, 8793 (2015). Brunel, S. et al. In this debated framework, Gravettian-associated individuals have been suggested to represent a biologically homogeneous population on the basis of craniometric and genomic data4,22. A series of f4-symmetry statistics confirm that all the Epigravettian-associated individuals are cladal, and do not share excess affinity with any local (Paglicci 12) or non-local preceding ancestries (Goyet Q116-1, Kostenki 14, Malta 1 or Vstonice) (Supplementary Data 2.F). Genome Res. Biol. Kotula, A., Piezonka, H. & Tergerger, T. The Mesolithic cemetery of Gro Fredenwalde (north-eastern Germany) and its cultural affiliations. I have an undergraduate degree in pharmacology from the University of Toronto. We thus modelled individuals belonging to the GoyetQ2 cluster and El Mirn as a mixture between the Fournol 85 and Arene Candide 16 genomes as proxies to represent the Fournol and Villabruna ancestries, respectively, in Magdalenian-associated groups (Fig. Article Biol. (2023, March 1). This button displays the currently selected search type. My name is Tina and I'm a data scientist at a FAANG company. Data warehousing is a relatively new field that focuses on the use of large datasets for analytical purposes. The genetic history of Ice Age Europe. Curr. It is often considered as a pan-European cultural mosaic with regional variations in material to symbolic productions20,21. Shes currently at Microsoft. Nature 513, 409413 (2014). wrote the manuscript with input from T.T., E.A., W.H., J. Krause and all other co-authors. 359, 318 (2015). This suggests that the newly reported Neolithic individual from central Asia carries an ancestry that might be a good proxy for the ANE-related contribution to Iran and the Turan region45 from around 5.5ka but not to roughly contemporaneous hunter-gatherers from eastern Europe. Second, the ancestry of individuals associated with the Epigravettian culture (Villabruna cluster), which was found to genetically connect European and Near Eastern hunter-gatherers, reached southern Europe well before the transition between the Early and Late Epigravettian4,15 and possibly as early as the GravettianEpigravettian transition. Finally, we estimated the genetic diversity of Epigravettian-associated individuals in the dataset by calculating both pairwise mismatch rates (PMR) on pseudo-haploid genotypes and individual heterozygosity levels on pseudo-diploid genotypes (Supplementary Data 3.A). Dolukhanov, P. in Cultural Transformations and Interactions in Eastern Europe (eds Chapman, J. Antonio, M. L. et al. Required fields are marked *. In particular, the model achieves 96.21% for the validation and 96.47% for testing using the news aggregator data. a, MDS plot of pre-LGM individuals. 39, msac017 (2022). 5). Single-stranded DNA libraries were built from 30l of DNA extract in the absence of uracil DNA glycosylase (ss_nonUDG) followed by double indexing, using an automated version of the protocols described in61 on the liquid handling system mentioned before. The newly generated genotypes were merged with 240 published ancient hunter-gatherer genomes and modern worldwide populations for downstream analyses (Supplementary Data 1.G). Tina Huang I'm a data scientist, youtuber, and the first Lonely Octopus . Patterson, N. et al. 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