4. DOSAGE AND ADMINISTRATION: Venofer must only be administered intravenously either by slow injection or by infusion. Serious - Use Alternative (1)iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. Use Caution/Monitor. May increase risk of hypotension. Use Caution/Monitor. PDF PRODUCT MONOGRAPH - pdf.hres.ca Applies only to oral form of both agents. Elemental iron product this is a choice between three iron supplement products: Iron dextran 50 mg/mL, Iron sucrose 20 mg/mL and Ferric gluconate 12.5 mg/mL. In: Koda-Kimble & Young's Applied Therapeutics: The Clinical Use of Drugs. When to Use Weight lbs Target hemoglobin g/dL Actual hemoglobin g/dL Iron stores Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg mg Result: Please fill out required fields. sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Drug Dosing in Obesity Reference Table - ClinCalc.com To provide clinicians with evidence-based guidance for iron therapy dosing in patients with iron deficiency anemia (IDA), we conducted a study examining the benefits of a higher cumulative dose of intravenous (IV) iron than what is typically administered. Use Caution/Monitor.Minor (2)calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. Med J Aust; 193(9):525-32. By using this form you agree with the storage and handling of your data by this website. Feraheme, when added to intravenous infusion bags containing either 0.9% Sodium Chloride Injection, USP (normal saline), or 5% Dextrose Injection, USP, at concentrations of 2-8 mg elemental iron per mL, should be used immediately but may be stored at controlled room temperature (25C 2C) for up to 4 hours or refrigerated (2-8 C) for up to 48 hours. Avoid or Use Alternate Drug. Med J Aust. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Applies only to oral form of both agents. Use Caution/Monitor. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS Fatal and serious hypersensitivity reactions including anaphylaxis have occurred in patients receiving Feraheme. Serious - Use Alternative (1)iron sucrose decreases levels of tetracycline by inhibition of GI absorption. Found in multiple references. Applies only to oral form of both agents. The recommended dosage of iron sucrose for repletion of iron deficiency in patients undergoing hemodialysis is 5ml of iron sucrose (100mg of elemental iron) delivered intravenously during the dialysis session. https://www.uptodate.com/ (Requires subscription). For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet. UpToDate. Use Caution/Monitor. Venofer treatment may be repeated if iron deficiency reoccurs. Official Journal of the International Society of Nephrology. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hgb conc. DailyMed - VENOFER- iron sucrose injection, solution Only administer Feraheme as an intravenous infusion over at least 15 minutes and only when personnel and therapies are immediately available for the treatment of anaphylaxis and other hypersensitivity reactions. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. Dosage Calculator - [100% Free] - Calculators.io 1000 mg. 20 MINUTES. Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl over a period of 15 minutes. Treatment of anemia due to iron deficiency. gymnema decreases levels of iron sucrose by inhibition of GI absorption. LBW = Lean body weight in kg. Formula for calculating the required dose of iron sucrose Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. Individual doses of 2 mL or less may be given on a daily basis until the calculated total amount required has been reached. Pediatric Patients: The most common adverse reactions (2%) are headache, respiratory tract viral infection, peritonitis, vomiting, pyrexia, dizziness, cough, nausea, arteriovenous fistula thrombosis, hypotension and hypertension. Applies only to oral form of both agents. lansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Iron sucrose: 20 mg/mL. iron sucrose, captopril. Where C= concentration of elemental iron (mg/ml) in the product being used: Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events, Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD), Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD), WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS, Iron Deficiency and Anemia- signs and therapeutic options. Venofer is given as an infusion into a vein. Crown Rump Length and Nuchal Translucency. -Hgb deficit (grams) = Hgb deficit (g/dL) x blood volume (dL) -Iron deficit (mg) = Hgb deficit (grams) x 3.3 (mg Fe/g Hgb) [Note: 3.3 x 0.65 = 2.145] Applies only to oral form of both agents. Venofer treatment may be repeated if necessary. Avoid or Use Alternate Drug. Intravenous therapy is preferred for urgent intervention and when oral iron cannot be absorbed or the patient suffers from chronic renal impairment. Applies only to oral form of both agents. Minor/Significance Unknown. Minor/Significance Unknown. In this study and another study evaluating a single intravenous dose of iron sucrose containing 500-700 mg of iron in 26 anemic patients on erythropoietin therapy (23 female, 3 male; age range 16-60), approximately 5% of the iron was . Monitor Closely (1)didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. Monitor Closely (1)ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Taking the case of a patient weighing 75 kg (165.3 lbs) with a target hemoglobin value of 13 g/dL (130 g/L or 8.07 mmol/L), an actual hemoglobin of 9.5 g/dL (95 g/L or 5.9 mmol/L) and iron stores of 500 mg, the iron deficit is: Iron deficit = 75 x (13 9.5) x 2.4 + 500 = 1,130 mg. May increase risk of hypotension. Administer a test INFeD dose prior to the first therapeutic dose. Minor/Significance Unknown. Use INFeD only in patients in whom clinical and laboratory investigations have established an iron deficient state not amenable to oral iron therapy. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Applies only to oral form of both agents. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Echocardiogram Z Score (NEW)(BETA TESTING) Edinburgh Postnatal Depression Scale. Alternatively the total dose may be calculated: Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW) Based on: Desired Hb = the target Hb in g/dl. Oral iron therapy is the first method while IV therapy comes in place when there are contraindications or the body doesnt respond to the oral one. Fulminant symptoms include confusion, sensation of passing out, paleness. The original formula employs the weight in kg but users can input it in lbs and it gets transformed. Administer Injectafer intravenously, either as an undiluted slow intravenous push or by infusion. Use Caution/Monitor. Most studies have used IV iron sucrose (maximum dose of 200 mg per setting) or ferric carboxymaltose (maximum dose of 1000 mg per week). Applies only to oral form of both agents. Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. commonly, these are "non-preferred" brand drugs or specialty Although anaphylactic reactions known to occur following INFeD administration are usually evident within a few minutes, or sooner, it is recommended that a period of an hour or longer elapse before the remainder of the initial therapeutic dose is given. Drug: Comments: A: Acyclovir 1: Dose using a 40% adjusted body weight; Amikacin 2: Dose using a 40% adjusted body weight; Amphotericin B (liposomal) 3 Consider capping body weight to 100 kg; Atracurium 4: Dose using ideal body weight; The use of ideal body weight has been shown to be associated with a more predictable muscle strength recovery within 60 minutes and a lack of need for antagonism . Chandler G, Harchowel J, Macdougall I. Minor/Significance Unknown. Iron sucrose | Drugs | BNF | NICE It should be recognized that iron storage may lag behind the appearance of normal blood morphology. Do not mix iron sucrose with other medications or TPN solution. Iron deficiency can occur at any stage of life, due to physiological demands, for example, during pregnancy, childhood growth or prolonged periods of sickness. an automated flowchart approach. Modify Therapy/Monitor Closely. 2. Multiple placebo-controlled, randomized clinical trials have been conducted with IV iron in patients with New York Heart Association class II-III heart failure with an ejection fraction 45% who met criteria . Most sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. The total amount of INFeD in mL required to treat the anemia and replenish iron stores may be approximated as follows: Adults and Children over 15 kg (33 lbs): See Dosage Table. Discard unused portion. If dose exceeds 20mg/kg it should be rounded down to 20mg/kg OR administration of the total dose has to be split and given 7 days apart. Interaction only with oral iron administration. Applies only to oral form of both agents. omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Patients may present with shock, clinically significant hypotension, loss of consciousness and/or collapse. Parenteral iron dose - UpToDate On the other hand, slow decreases, such as that in chronic occult gastrointestinal bleeding are often difficult to diagnose. Intravenous iron sucrose: establishing a safe dose - PubMed Applies only to oral form of both agents. This document does not contain all possible drug interactions. Fill in the calculator/tool with your values and/or your answer choices and press Calculate. aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. The dosage of Venofer is expressed in mg of elemental iron. Use Caution/Monitor. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Either increases effects of the other by pharmacodynamic synergism. Option 2: 200 mg in NS 100 mL administered over 20-30 minutes; may repeat every other day to The dose of Venofer must be individually calculated for each patient according to the total iron deficit calculated with the following Ganzoni formula, for example: Total iron deficit [mg] = BW [kg] x (target Hb - actual Hb) [g/dl] x 2.4* + storage iron [mg] Below 35 kg BW: 35 kg BW and above: Target Hb = 13 g/dl and storage iron = 15 mg/kg BW Hemoglobin iron deficit = 60 x (14 - 8) x (2.145) = 772 mg iron. Methods: We reviewed the experience of our department between January, 2011 and February, 2014 with the use of intravenous iron sucrose in children 14 years of age who failed in oral iron therapy for iron deficiency anemia (IDA). Please note that once you have closed the PDF you need to click on the Calculate button before you try opening it again, otherwise the input and/or results may not appear in the pdf. USES: This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. Suggested regime: Prescribing instructions Prescribing a single/first dose: 1982;13(4):309-21. Minor (1)iron sucrose decreases levels of manganese by inhibition of GI absorption. Give each dose as 750 mg for a total cumulative dose of 1500 mg of iron per course. This health tool computes the iron deficit based on patient parameters and the Ganzoni formula. Oral and parenteral products - see background option for oral products. trientine, iron sucrose. famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Schweiz Med Wochenschr; 100(7):301-3. Manage and view all your plans together even plans in different states. Iron Injection Administration | INJECTAFER HCP IV iron products (adults) - UpToDate Minor/Significance Unknown. Use Caution/Monitor. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling [16.2].) Modify Therapy/Monitor Closely. David McAuley, Pharm.D. Iron supplements, whether administered orally, intramuscular or intravenous, are used to replenish body stores and correct anemia. iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. Venofer (iron sucrose) dose calculator | Calculosaurus.com Clinical calculators for obstetrics and gynaecology VTE risk assessment Calculator menu Venofer dose calculator Iron sucrose Not what you were looking for? World J Gastroenterol; 16(22): 27202725. Aranesp (darbepoetin alfa) | Dosing Considerations Avoid or Use Alternate Drug. Hypotension following administration of Venofer may be related to rate of administration and/or total dose delivered. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Intravenous iron-dextran: therapeutic and experimental possibilities [in German] Schweiz Med Wochenschr. Am J Hosp Pharm. Applies only to oral form of both agents. FOR PATIENTS WEIGHING 50 kg OR MORE: Administer 1000 mg of Monoferric by intravenous infusion 20 minutes as a single dose 1. Applies only to oral form of both agents. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. Avoid or Use Alternate Drug. iron sucrose increases levels of calcium carbonate by enhancing GI absorption. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Applies only to oral form of both agents. Applies only to oral form of both agents. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14. iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. Patients with a history of drug allergy or multiple drug allergies may be at increased risk of anaphylactic-type reactions to INFeD. Do not double the dose to catch up. The dosing for iron replacement treatment in pediatric patients with hemodialysis-dependent chronic kidney disease (HDD-CKD), non-dialysis-dependent chronic kidney disease (NDD-CKD) or peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD) has not been established. The factor 2.4 is derived from the following assumptions: a) Blood volume 70 ml/kg of body weight ~7% of body weight b) Iron content of hemoglobin 0.34% Factor 2.4 = 0.0034 x 0.07 x 10000 (conversion for g/dL) Ganzoni AM. Nutr Clin Pract. If no signs or symptoms of anaphylactic-type reactions follow the test dose, administer the full therapeutic INFeD dose. Applies only to oral form of both agents. Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. 1996 Aug;11(4):139-46. Learn how to store and discard medical supplies safely. Below the form there are further instructions on how to use the calculator. Serious - Use Alternative (1)iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. Separate dosing of tetracyclines from these products. Venofer is manufactured under license from Vifor (International) Inc., Switzerland. The dose of Ferinject is based on calculation of ideal body weight and calculation of iron deficit using the Ganzoni formula. 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. The elemental iron product used is Iron sucrose 20 mg/mL. 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dosage Recommended dosage for patients weighing 50kg (110lb) or more: Give Injectaferin two doses separated by at least 7 days. Iron sucrose: 20 mg/mL. Anemia. vonoprazan will decrease the level or effect of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents. FERAHEME was non-inferior to Venofer (iron sucrose) in mean Hgb rise from baseline 2,5. These can be input in g/dL, g/L or mmol/L. Minor/Significance Unknown.iron sucrose increases levels of calcium chloride by enhancing GI absorption. HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication. Foods rich in iron include meats (especially liver), eggs, raisins, figs, broccoli, brussels sprouts, beans, lentils, and iron-fortified or enriched cereals. Intravenous iron therapy for patients with anemia Our dosage calculator can help you with this as well. Applies only to oral form of both agents. Applies only to oral form of both agents. Minor (2)calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. You may need extra iron because of blood loss during kidney dialysis. Dr. Ganzonis primary research is focused on iron deficiency and plasma iron transport. Brand name: Venofer Drug class: Iron Preparations Chemical name: iron saccharate CAS number: 8047-67-4 Medically reviewed by Drugs.com on Oct 25, 2022. * Adapted from the KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. Prescribing and dispensing information For iron sucrose A complex of ferric hydroxide with sucrose containing 2% (20 mg/mL) of iron. Volume of iron sucrose needed = 60 x (14 - 8) x (2.145) 20 = 38.6 mL . Minor/Significance Unknown. Human studies not conducted. Use alternatives if available. Minor/Significance Unknown. Use alternatives if available. calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. The above information is provided for general Applies only to oral form of both agents.
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