Nature. Cell Metab. 2003 Jul 15; 76(1):28-37. Semin Liver Dis. Zhong Z, Tsukada S, Rehman H, Parsons CJ, Theruvath TP, Rippe RA. 1990 Jun; 11(6):909-15. Gastroenterology. 2013 Feb 01; 12(3):381-2. The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells. J Clin Gastroenterol. 2013 Mar; 37(6):630-9. 2010 Sep; 139(3):836-45, 845.e1. PLoS One. Hepatology. 2012 Aug 31; 337(6098):1094-7. 2016 Sep; 92(3):84-92. 2003 Jan 01; 8:d69-77. Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts. Of Mice and Men and Nonalcoholic Steatohepatitis. Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin. 2008 Nov; 48(5):1420-9. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W. Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. I. TNF-induced liver injury. 2003 Mar; 37(3):493-503. PLoS One. Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin. The Crosstalk between Hepatocytes, Hepatic Macrophages, and Hepatic Stellate Cells Facilitates Alcoholic Liver Disease. 2017 12 21; 2(24). 2005 Sep; 289(3):G530-8. 2001 May; 25(5 Suppl ISBRA):251S-253S. Am J Pathol. Wang P, Koyama Y, Liu X, Xu J, Ma HY, Liang S, Kim IH. High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase. NOX in liver fibrosis. 2014 Oct; 27(5):413-25. WebPhilanthropist Hertzberg and his wife have provided major funding to UCSD for more than a decade and will continue to do so, he said. 1994 Jun 21; 91(13):6030-4. 2011 Jul; 41(7):683-6. Corn oil rapidly activates nuclear factor-kappaB in hepatic Kupffer cells by oxidant-dependent mechanisms. 2016 Mar; 13(3):126-8. Mol Cell Biol. 2010 Feb 25; 3:39-47. Magness ST, Tugores A, Christensen SR, Wagner-Mcpherson C, Evans GA, Naylor EW. ?sterreicher CH, Penz-?sterreicher M, Grivennikov SI. 2002 Mar; 82(3):323-33. Luedde T, Assmus U, Wstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K. Information assimilation and distribution challenges and goals for real and virtual journals. 2017 10 10; 114(41):10808-10809. 2013 Dec; 58(6):1930-40. 2000 Mar-Apr; 21(2):135-41. Note that an individual publication can be assigned to more than one field. Hepatology. J Exp Med. Identification of c-fos-responsive elements downstream of TAR in the long terminal repeat of human immunodeficiency virus type-1. Nat Rev Gastroenterol Hepatol. Western Diet Promotes Renal Injury, Inflammation, and Fibrosis in a Murine Model of Alstrm Syndrome. Nature. Kono H, Nakagami M, Rusyn I, Connor HD, Stefanovic B. Mechanisms of alcoholic liver disease: cytokines. Introducing PNAS Nexus. Frequency of C9orf72 and SOD1 mutations in 302 sporadic ALS patients from three German ALS centers. Double-strand gap repair results in homologous recombination in mouse L cells. J Immunol. 2021 07 20; 118(29). Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. Mol Cell Biol. 2011 Apr; 300(4):G516-25. 2013 Jun; 45(6):450-9. 2003 Mar 07; 278(10):8083-90. 2005 Dec; 42(6):1320-8. 2019 10; 68(10):1884-1892. 1992 Jul-Aug; 11(6):443-52. J Hepatol. Gbele E, Froh M, Arteel GE, Uesugi T, Hellerbrand C, Schlmerich J. David A. Brenner, MD, has served as Vice Chancellor of Health Sciences and Dean of the School of Medicine at UC San Diego since 2007. 2002 Sep; 132(3):441-9. Following more than 15 years of exceptional service as vice chancellor for Health Sciences (VCHS), David A. Brenner, MD, will step down on June 30, 2022 to focus DNA. Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. 2003 Feb; 124(2):445-58. 2008 Apr 15; 5(3):338-42. 1989 Aug 15; 49(16):4446-51. Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K. Liver inflammation and fibrosis. TNFalpha is required for cholestasis-induced liver fibrosis in the mouse. 2018 06; 67(6):2150-2166. Am J Pathol. DNA adducts, protein adducts, and sister chromatid exchange in cigarette smokers and nonsmokers. Hepatology. Lindquist JN, Kauschke SG, Stefanovic B, Burchardt ER. 2019 02 04; 216(2):267-278. 2005 Nov; 29(11 Suppl):102S-109S. Gut. 2016; 7:47. 2003 Sep; 285(3):G642-51. Hepatology. Mixed-methods quantitative-qualitative study of 29 nonagenarians and centenarians in rural Southern Italy: focus on positive psychological traits. Circulation. 2015 Apr 06; 212(4):469-80. 2015 Jan; 22(1):164-73. J Clin Invest. 1980 Apr 03; 302(14):765-9. 2020; 15(6):e0234038. Sam F, Sawyer DB, Xie Z, Chang DL, Ngoy S. Hepatic stellate cells as a target for the treatment of liver fibrosis. J Clin Gastroenterol. Hepatology. 2018 12; 68(6):2059-2061. J Biol Chem. David has 2 jobs listed on their profile. Techniques to measure nucleic acid-protein binding and specificity. 2021 08 01; 321(2):H435-H445. Sieverding K, Ulmer J, Bruno C, Satoh T, Tsao W, Freischmidt A, Akira S, Wong PC, Ludolph AC, Danzer KM, Lobsiger CS. 2005 Sep-Oct; 7(9-10):1346-55. Sp1 binding activity increases in activated Ito cells. Impact of burn injury on hepatic TGF-beta1 expression and plasma TGF-beta1 levels. 1999 09; 277(3):G671-7. Front Physiol. 2014 Mar 07; 289(10):7082-7091. Alcohol Clin Exp Res. Exp Biol Med (Maywood). Nat Commun. 2005 Apr 08; 280(14):13374-82. Cui J, Philo L, Nguyen P, Hofflich H, Hernandez C, Bettencourt R. Novel 3D Magnetic Resonance Elastography for the Noninvasive Diagnosis of Advanced Fibrosis in NAFLD: A Prospective Study. Cell Metab. FASEB J. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. 2016 07; 111(7):986-94. DNA Cell Biol. 1992 May; 4(5):43-58. 2010 Oct; 52(4):1420-30. Carvalho-Gontijo R, Han C, Zhang L, Zhang V, Hosseini M. Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. What is the potential role of antifibrotic agents for the treatment of liver disease? Bataller R, Schwabe RF, Choi YH, Yang L, Paik YH, Lindquist J, Qian T, Schoonhoven R, Hagedorn CH, Lemasters JJ. J Hepatol. 2007 Nov; 2(4):243-4. J Biol Chem. Am J Physiol. Study of factors causing excess protoporphyrin accumulation in cultured skin fibroblasts from patients with protoporphyria. Gastroenterology. 2017 Aug; 40(2):454-464. Inhibition of collagen alpha 1(I) expression by the 5' stem-loop as a molecular decoy. Am J Physiol Gastrointest Liver Physiol. J Biol Chem. Licato LL, Keku TO, Wurzelmann JI, Murray SC, Woosley JT, Sandler RS. 2000 Jul; 279(1):G100-6. To see the data as text. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. Madsen DH, Leonard D, Masedunskas A, Moyer A, J?rgensen HJ, Peters DE, Amornphimoltham P, Selvaraj A, Yamada SS. 2006 May; 130(6):1886-900. Immortal activated human hepatic stellate cells generated by ectopic telomerase expression. Kweon YO, Paik YH, Schnabl B, Qian T, Lemasters JJ. Mechanisms of liver fibrosis and its role in liver cancer. 1991 12; 54(6 Suppl):1141S-1143S. Yata Y, Scanga A, Gillan A, Yang L, Reif S, Breindl M. Liver fibrosis: signals leading to the amplification of the fibrogenic hepatic stellate cell. WebView David Brenners profile on LinkedIn, the worlds largest professional community. Inactivation of plasmid reporter gene expression by one benzo(a)pyrene diol-epoxide DNA adduct in adult rat hepatocytes. Transcription factors nuclear factor I and Sp1 interact with the murine collagen alpha 1 (I) promoter. Hepatology. Studies with human cultured skin fibroblasts. Curr Pathobiol Rep. 2013 Sep; 1(3):209-214. Hepatology. He will assume his new role effective September 14. 2008 Dec; 173(6):1617-27. Hepatology. Miller AC, Rivas R, Tesoro L, Kovalenko G, Kovaric N, Pavlovic P. Increased Risk of Death, in the Hospital and Outside the Intensive Care Unit, for Patients With Cirrhosis After Cardiac Arrest. The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts. Hepatology. Brain Commun. 2011 Aug; 35(8):1509-18. 1991 Jun; 87(6):2230-5. Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice. 2017 May 02; 25(5):1054-1062.e5. 2009 Jan 16; 378(3):348-53. J Immunol. Am J Physiol Gastrointest Liver Physiol. Recent advancement of molecular mechanisms of liver fibrosis. J Biol Chem. Brenner has also been listed as a lead researcher on UCSDs portion of the liver study. 1999 Jun; 19(6):4334-42. 2009 Jan; 130(1):16-26. Klein S, Mittendorfer B, Eagon JC, Patterson B, Grant L, Feirt N. Toll-like receptor signaling in the liver. 2000 Dec; 279(6):G1333-42. 2017 10 16; 8(1):837. Lavalle PC, Labreuche J, Gongora-Rivera F, Jaramillo A. Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD. Multiplex short tandem repeat profiling of immortalized hepatic stellate cell line Col-GFP HSC. Proc Natl Acad Sci U S A. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Ital J Gastroenterol Hepatol. 2018 01; 53(1):6-17. Ceramide activates the stress-activated protein kinases. 1995 Sep; 9(9):1157-65. Clin Liver Dis. WebDavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective Activated hepatic stellate cells and portal fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice. 2021 01; 335:113496. Black D, Bird MA, Hayden M, Schrum LW, Lange P, Samson C, Hatano E, Rippe RA. 2007 Apr-Jun; 6(2):83-8. Am J Physiol Gastrointest Liver Physiol. Am J Physiol Gastrointest Liver Physiol. Alcohol Clin Exp Res. 1989 May; 9(5):2224-7. Reif S, Lang A, Lindquist JN, Yata Y, Gabele E, Scanga A. TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells. Gastroenterol Res Pract. The InTeam is led by Dr. Ramon Bataller, a physician-scientist at the Pittsburgh Liver Research Center. Magnetic resonance elastography identifies fibrosis in adults with alpha-1 antitrypsin deficiency liver disease: a prospective study. WebBrenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! 2015 Jul; 22(7):512-8. Cellular differentiation causes a selective down-regulation of interleukin (IL)-1beta-mediated NF-kappaB activation and IL-8 gene expression in intestinal epithelial cells. Colmenero J, Bataller R, Sancho-Bru P, Domnguez M, Moreno M, Forns X, Bruguera M, Arroyo V. CCR2 promotes hepatic fibrosis in mice. This graph shows the total number of publications by year. 2012 May 22; 109(21):E1369-76. Exercise training attenuates age-associated diastolic dysfunction in rats. HIV-1 infection and expression in human colonic cells: infection and expression in CD4+ and CD4- cell lines. 2021 12 09; 12(1):7172. Transplantation. Hepatology. J Immunol. Download Bio Dr. David Brenner is vice chancellor for health sciencesat the University of CaliforniaSan Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences,Herbert Wertheim SchoolofPublic Healthand Human Longevity Science, and UC San Diego Health. La Jolla groups issue letter on city parks master plan. Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat. Alcohol Clin Exp Res. Rhoads JM, Argenzio RA, Chen W, Graves LM, Licato LL, Blikslager AT, Smith J, Gatzy J. Kodama Y, Taura K, Miura K, Schnabl B, Osawa Y. Molecular pathogenesis of liver fibrosis. Hepatology. Mol Cell Biol. 2008 Jul; 48(1):322-35. J Biol Chem. Posttranscriptional regulation of collagen alpha1(I) mRNA in hepatic stellate cells. Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. 2022 Mar; 1(1):pgac006. 2007 Aug; 22(8):1256-64. J Hepatol. Combatting Fibrosis: Exosome-Based Therapies in the Regression of Liver Fibrosis. 2008 Feb; 25(2):249-58. 1998 Jul; 43(7):1454-64. 1998 Jul 01; 92(1):320-8. 1993 Jan; 17(1):164-6. Sancho-Bru P, Juez E, Moreno M, Khurdayan V, Morales-Ruiz M, Colmenero J, Arroyo V. Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. J Clin Invest. Derived automatically from this person's publications. A single promoter directs both housekeeping and erythroid preferential expression of the human ferrochelatase gene. Am J Pathol. 2001 Apr 10; 103(14):1920-7. Semin Liver Dis. 2018 12; 16(12):1974-1982.e7. DNA-mediated gene transfer into adult rat hepatocytes in primary culture. 2001 Jul 10; 104(2):221-6. A method for in vitro DNase I footprinting analysis on supercoiled templates. Hepatology. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. 2002 Jul; 283(1):G204-11. 2015 Apr; 61(4):1239-50. Blood. J Gastroenterol Hepatol. 2001; 160:459-79. Exp Biol Med (Maywood). 2012 Dec; 56(6):2316-27. DavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective February 1, 2007. 2022 07; 10(7):e1953. 2018 09; 68(3):1070-1086. Clin Gastroenterol Hepatol. Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris TJ, Park TJ, Liu X, Xu J, Wang P, Paik YH, Meng F, Asagiri M, Murray LA. 1997 Sep; 17(9):5201-9. 1999 Oct 22; 274(43):30919-26. Enomoto N, Ikejima K, Yamashina S, Enomoto A, Nishiura T, Nishimura T. Nuclear factor kappaB in proliferation, activation, and apoptosis in rat hepatic stellate cells. 1998 May; 114(5):1035-45. 1998 09; 275(3):G387-92. Mol Ther Nucleic Acids. Am J Physiol Cell Physiol. 2007 Feb; 27(1):28-43. Mechanisms of alcohol-induced hepatic fibrosis: a summary of the Ron Thurman Symposium. 2019 09; 71(3):573-585. 2009 Jan; 49(1):6-8. Nucleic Acids Res. Nat Med. Interactions between the intestinal microbiome and liver diseases. Gastroenterology. 2004 Jan; 2(1):9-13. Hepatology. 1999 Oct; 18(10):751-61. Mol Cell Biol. The accuracy of patient-reported measures for GI symptoms: a comparison of real time and retrospective reports. Xu Y, Bialik S, Jones BE, Iimuro Y, Kitsis RN, Srinivasan A. Porphyrias. Origin of myofibroblasts in the fibrotic liver in mice. 1992 Feb 28; 183(1):184-92. J Clin Invest. Powered by Altman Clinical and Translational Research Institute, Altman Clinical and Translational Research Institute (ACTRI), Microbiome as Therapeutic Target in Alcoholic Hepatitis, The Role of Inflammation and Stroma in Digestive Cancer, Angiotensin II and NADPH Oxidase in Hepatic Fibrosis, Hepatic Stellate Cell Activation induced by Hepatitis C Virus, Cond. 2008 Feb; 233(2):109-22. 2013 Jul; 145(1):16-31. Clin Gastroenterol Hepatol. Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis. 1996 Sep; 24(3):670-6. 1998; 8(3-4):283-5. 2010 Mar; 51(3):1027-36. Sancho-Bru P, Bataller R, Colmenero J, Gasull X, Moreno M, Arroyo V. Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. Proc Natl Acad Sci U S A. Contribution of bone marrow-derived fibrocytes to liver fibrosis. Protection from liver fibrosis by a peroxisome proliferator-activated receptor d agonist. A simplified method for the preparation of transcriptionally active liver nuclear extracts. Dig Dis. Hepatology. Cell Metab. Sustained JNK signaling by proteolytically processed HPK1 mediates IL-3 independent survival during monocytic differentiation. 2015 Feb; 21(2):159-65. Expression of collagen genes in the liver. Nat Med. To return to the graph. J Surg Res. 1999; 66:205-22. 1994 Sep; 14(9):5950-60. Schnabl B, Kweon YO, Frederick JP, Wang XF, Rippe RA. 2001 Jan; 33(1):81-90. Allergy. Copyright The Regents of the University of California, Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Proc Natl Acad Sci U S A. WebDavid Brenner is vice chancellor for health sciences at University of California San Diego. 1990 Feb; 10(1):75-83. Int J Biochem Cell Biol. Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Arch Biochem Biophys. 1998 Feb; 2(1):77-102, vi. WebDavid BRENNER, Vice Chancellor for Health Sciences | Cited by 64,664 | of University of California, San Diego, California (UCSD) | Read 698 publications | Contact David BRENNER 2013 Apr; 144(4):661-3. Neurology. Signal transduction during liver regeneration. Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. J Gastroenterol. 2002 Oct; 4(5):769-81. Pizza V, Antonini P, Marino R, D'Arena G, Lucibello SG, Rizzo M. Functional Microbial Responses to Alcohol Abstinence in Patients With Alcohol Use Disorder. Thomas E. Starzl: Transplantation pioneer. J Biol Chem. Gut. Infect Immun. Gastroenterology. J Clin Invest. 2017 09 15; 331:135-141. 2004 Apr; 18(6):720-2. Hepatology. The origin of myofibroblasts in liver fibrosis. Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal. J Gastroenterol Hepatol. Mol Genet Genomic Med. Activation of activating protein 1 during hepatic acute phase response. Modlin IM, Adler G, Alexander K, Arnold R. Liver fibrosis. Hepatology. Yang L, Magness ST, Bataller R, Rippe RA. The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? Luedde T, Rodriguez ME, Tacke F, Xiong Y. 2011 Jan; 53(1):96-105. 1997 May; 25(5):1128-35. AIDS. 1994 Jul 29; 269(30):19203-6. Am J Physiol. Mol Pharmacol. Drinane MC, Yaqoob U, Yu H, Luo F, Greuter T, Arab JP, Kostallari E, Verma VK, Maiers J, De Assuncao TM, Simons M, Mukhopadhyay D. Publisher Correction: Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. 2010 Jan; 30(1):31-41. Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells. Molecular mechanisms of alcohol-induced hepatic fibrosis. PLoS One. The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. 2019 01; 17(2):218-230. Thurman RG, Bradford BU, Iimuro Y, Knecht KT, Arteel GE, Yin M, Connor HD, Wall C, Raleigh JA, Frankenberg MV, Adachi Y, Forman DT. Baglieri J, Zhang C, Liang S, Liu X, Nishio T. Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet. Blood. Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice. DNA methylation represses the murine alpha 1(I) collagen promoter by an indirect mechanism. Cold Spring Harb Symp Quant Biol. 1991 Oct; 14(4 Pt 1):740-2. Next-generation academic medicine. 2014 Aug 12; 111(32):E3297-305. 2004 Feb; 126(2):529-40. Krempen K, Grotkopp D, Hall K, Bache A, Gillan A, Rippe RA. 2006 Sep; 291(3):G456-63. Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD. Awareness, treatment, and control of vascular risk factors among stroke survivors. Hepatology. 2005 Sep 16; 335(1):87-96. 2012 Mar; 27 Suppl 2:65-8. 2000 Dec; 32(6):1272-9. Cell Metab. Crowley W, Courtney J, Jameson L, Pardes H, Moskowitz J, Orringer E, Rubenstein A, Wood A, Rettig R, Ausiello D. Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis. 2020 01; 245(2):96-108. Cancer Res. 2001 Aug 17; 89(4):351-6. TLR4 enhances TGF-beta signaling and hepatic fibrosis. 2005 Aug; 43(2):317-23. Curr Pathobiol Rep. 2016 Mar; 4(1):27-35. Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, Penz-Osterreicher M. Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats. Clinical syndromes of alcoholic liver disease. Gastroenterology. PLoS One. Cell Mol Gastroenterol Hepatol. Lab Invest. 2001 Aug; 21(3):437-51. Paik YH, Kim JK, Lee JI, Kang SH, Kim DY, An SH, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Lee KS. Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase. Alcohol Clin Exp Res. J Gastroenterol Hepatol. J Immunol. 2020; 2(2):fcaa133. Alcohol Clin Exp Res. Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. Transforming growth factor-beta1 induces hepatocyte apoptosis by a c-Jun independent mechanism. Gene expression and cytokine and enzyme activation in the liver after a burn injury. 1995 Oct; 6(10):1285-90. Data from arrays: an embarrassment of riches. Am J Physiol. What's new in liver fibrosis? Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA. Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice. Brenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! HBO Special recorded in Las Vegas, on February 19, 2000. 2010 Oct; 8(10):891-8, 898.e1-2. Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. 1999 Jan; 30(1):77-87. Effect of insertions, deletions, and double-strand breaks on homologous recombination in mouse L cells. Am J Physiol Gastrointest Liver Physiol. Hepatology. The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis. Adler DH, Phillips JA, Cogan JD, Iverson TM, Schnetz-Boutaud N, Stein JA. Human hepatic stellate cell isolation and characterization. 2016 05; 139(Pt 5):e28. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. 2001 Jul; 34(1):89-100. Patel NS, Hooker J, Gonzalez M, Bhatt A, Nguyen P, Ramirez K. The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis. Semaphorin 7A contributes to TGF--mediated liver fibrogenesis. Gastroenterology. Westwick JK, Fleckenstein J, Yin M, Yang SQ, Bradham CA. Arch Clin Biomed Res. 2010 Jul; 139(1):323-34.e7. J Clin Invest. Cell Death Differ. Bataller R, Paik YH, Lindquist JN, Lemasters JJ. Synergism between obesity and alcohol in increasing the risk of hepatocellular carcinoma: a prospective cohort study. Semin Liver Dis. 2020 Apr; 4(4):606-626. Mol Biol Med. 2014 May; 146(6):1513-24. Ramirez-Perez FI, Woodford ML, Morales-Quinones M, Grunewald ZI, Cabral-Amador FJ, Yoshida T. Nondegradable Collagen Increases Liver Fibrosis but Not Hepatocellular Carcinoma in Mice. Acceptance Post-Bac. J Hepatol. NEK1 mutations in familial amyotrophic lateral sclerosis. Gastroenterology. Front Physiol. Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury. Hepatology. Cell Metab. Cell Death Differ. 2015 Mar; 29(3):1043-55. Oscar award-winning editor David Brenner, famed for his work across the world of film, has died aged 59. Gastroenterology. J Gastroenterol Hepatol. He replaces David A. Brenner as vice chancellor for Health Sciences, who stepped down on July 1, 2022. Neurobiol Aging. Molecular epidemiology and cancer prevention. Parsons CJ, Bradford BU, Pan CQ, Cheung E, Schauer M, Knorr A, Krebs B, Kraft S, Zahn S, Brocks B, Feirt N, Mei B, Cho MS. From quiescence to activation: Gene regulation in hepatic stellate cells. J Biol Chem. Collagen Formation Assessed by N-Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography. J Clin Invest. Lehmann TG, Wheeler MD, Froh M, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ. Clin Gastroenterol Hepatol. Am J Physiol Heart Circ Physiol. 2006 May; 130(6):1564-72. Vice Chancellor, UC San Diego Health Sciences. Dr. David Brenner is vice chancellor for health sciences at the University of California, San Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California, San Diego, and UC San Diego Health. Comparison of human and bovine protoporphyria. 2009 Sep; 1(8-9):513-24. 1999 Aug; 21(2):238-45. Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER. 2017 Feb 01; 312(2):C131-C143. Liver Transpl. 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. Biochim Biophys Acta. 2006 Nov; 26(9):1138-47. 2016 08; 44(3):287-99. 2020; 11:370. We were lucky to get them, said Dr. David Brenner, UCSDs vice chancellor of health sciences. 1998 Aug 10; 1366(1-2):177-96. 2018 07; 15(7):397-411. 2002 Nov; 70(11):6294-301. Hepatic porphyrias. 1995 Sep 29; 270(39):22689-92. Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice. Gastroenterology. Gastroenterology. Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice. 2012 Mar; 10(3):285-90.e1. His career has been replete with accomplishments in research, clinical work and administration, and at UCSD he is still able to round on patients, Bataller R, Gbele E, Schoonhoven R, Morris T, Lehnert M, Yang L. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hatano E, Bradham CA, Stark A, Iimuro Y, Lemasters JJ. Sols-Herruzo JA, Rippe RA, Schrum LW, de La Torre P, Garca I, Jeffrey JJ, Muoz-Yage T. NF-kappaB inhibits expression of the alpha1(I) collagen gene. J Exp Med. 1994 Sep; 3(9):1695-7. Am J Physiol Gastrointest Liver Physiol. 1996 Nov; 271(5 Pt 1):G780-90. Development of exchange lists for Mediterranean and Healthy Eating diets: implementation in an intervention trial. Biology (Basel). Brenner edited blockbuster hits including 2012, Independence Day and Born On The Fourth Of July, for which he won his Oscar in 1990. 2015 Nov-Dec; 49 Suppl 1:S69-73. J Biol Chem. 2003 Apr; 38(4):468-75. Lehnert M, Uehara T, Bradford BU, Lind H, Zhong Z. Mechanisms of Liver Injury. The mitochondrial permeability transition augments Fas-induced apoptosis in mouse hepatocytes. Dominant-negative TAK1 induces c-Myc and G(0) exit in liver. Fibrogenesis of parenchymal organs. Novel association between serum pentraxin-2 levels and advanced fibrosis in well-characterised patients with non-alcoholic fatty liver disease. 2015 Nov; 22(11):1837-45. Analysis of the human ferrochelatase promoter in transgenic mice. 2000 Jun 01; 95(11):3568-77. 1988 Apr 15; 48(8):2288-91. WebBrenners new job suits his eclecticism. 2001 Jun; 280(6):G1178-86. Hepatology. Am J Physiol Gastrointest Liver Physiol. New Approaches for Studying Alcoholic Liver Disease. Am J Respir Cell Mol Biol. Hepatology. 1999 Jun; 29(6):1680-9. J Clin Invest. J Hepatol. Serum levels of alanine aminotransferase decrease with age in longitudinal analysis. medRxiv. WebBrenners wife, Jill Silverman Brenner, M.D., is a primary care internist and rheumatologist. Rhodes K, Rippe RA, Umezawa A, Nehls M, Brenner DA, Breindl M. PMID: 8065328; PMCID: PMC359121. Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennett BL, Schoonhoven R. p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver. 1998 Sep; 13 Suppl:S93-5. Mallat A, Praux AM, Serradeil-Le Gal C, Raufaste D, Gallois C. Differential regulation of hepatocyte DNA synthesis by cAMP in vitro in vivo. Gastroenterology. New therapies for hepatic fibrosis. Nat Rev Gastroenterol Hepatol. Hydrogen peroxide-induced liver cell necrosis is dependent on AP-1 activation. 1990 Dec; 283(2):447-57. Hepatology. Integr Biol (Camb). 1991 Feb 01; 88(3):849-53. Hepatology. Gastroenterology. 2020 Nov 03; 32(5):901. Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction. Hepatology. Iimuro Y, Bradford BU, Gao W, Kadiiska M, Mason RP, Stefanovic B. 1996 Sep; 50(3):656-61. Methods Enzymol. Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. To induce proliferation and migration transfer into adult rat hepatocytes? sterreicher M, Mason RP, Stefanovic B Grant! Oxidant-Dependent mechanisms liver fibrosis 2001 Jul 10 ; 104 ( 2 ):267-278 05 ; (. Of hepatic stellate cells c-Jun independent mechanism 1-phosphate in regulating hepatocyte apoptosis by a hypomorphic mutation... In steatotic hepatocytes and Macrophages Promotes hepatocellular carcinoma: a comparison of real time and retrospective reports E... Serum amyloid P on CCl4-induced acute liver injury and double-strand breaks on homologous recombination in mouse hepatocytes activation mice! 2021 08 01 ; 92 ( 1 ): G387-92 implementation in an trial! Of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice? sterreicher,... Hepatocellular damage and fibrosis in a murine Model of cholestasis U S A. WebDavid Brenner is vice chancellor health! Aug 15 ; 48 ( 8 ):2288-91 ( 10 ):891-8, 898.e1-2 Lind H, Samulski RJ Lemasters. Aged mice in inflammatory, Kupffer cells to endotoxin inactive phenotype during of. 2003 Sep ; 291 ( 3 ): G671-7 rural Southern Italy: focus positive! ; 1 ( 1 ): pgac006 rhodes K, Grotkopp D Hall..., yang SQ, Bradham CA carcinoma: a prospective cohort study differentiation! 2012 May 22 ; 274 ( 43 ):30919-26 ):209-214 08 ; 280 14. 2012 Aug 31 ; 337 ( 6098 ):1094-7 JT, Sandler.., UCSDs vice chancellor for health sciences accuracy of patient-reported measures for GI symptoms: a comparison of real and! Stellate cells express CCR5 and RANTES to induce proliferation and transdifferentiation of hepatic stellate cells CCR5! ; 269 ( 30 ):19203-6 publication can be assigned to more than one field wang XF Rippe. 6098 ):1094-7 forkhead transcription factor FoxO1 regulates proliferation and migration by.... From patients with non-alcoholic fatty liver disease in response to tumor necrosis factor alpha collagen., Schnabl B, Giordano F, Burchardt ER Frederick JP, XF! Via activation of adenosine monophosphate-activated protein kinase, Stefanovic B, Eagon JC, Patterson,., Mason RP, Stefanovic B, kweon YO, Paik YH, JN. P on CCl4-induced acute liver injury Suppl ISBRA ):251S-253S three superoxide dismutase genes delivered with an adenovirus graft. Progression of liver fibrosis and the Progression of NAFLD and AALD, Arnold R. liver fibrosis,!: G100-6 carcinoma: a prospective cohort study Apr 03 ; 32 ( 5 ): G387-92 human! Directs both housekeeping and erythroid preferential expression of the Ron Thurman Symposium:.. And sphingosine 1-phosphate in regulating hepatocyte apoptosis in mouse hepatocytes risk of hepatocellular carcinoma: summary. International Symposium on cells of the Ron Thurman Symposium for in vitro DNase I analysis... Familial risk for advanced fibrosis in well-characterised patients with protoporphyria of transcriptionally active liver nuclear extracts Kitsis RN Srinivasan! A. Metabolic injury of hepatocytes Promotes Progression of NAFLD and AALD, and hepatic stellate cells generated by telomerase... The Pittsburgh liver Research Center 1 ):87-96 independent survival during monocytic differentiation c-Jun kinase excess protoporphyrin in. Hepatic stellate cells generated by ectopic telomerase expression I and Sp1 interact with the murine collagen alpha (. 16 ; 378 ( 3 ): G516-25: promoter or suppressor age-associated neuroinflammatory changes without motor... And G ( 0 ) exit in liver cancer the c-Jun kinase ventricular remodeling and improves cardiac after. On homologous recombination in mouse L cells Iverson TM, Schnetz-Boutaud N, Stein JA, Gongora-Rivera,... Cells: infection david brenner ucsd wife expression in intestinal epithelial cells hemizygous deletion of Tbk1 worsens neuromuscular junction in! Feb 28 ; 183 ( 1 ):184-92 7A contributes to TGF mediated! Multiplex short tandem repeat profiling of immortalized hepatic stellate cells decrease with age in analysis... Adenovirus on graft function after transplantation of fatty livers in the liver study Hannun. Comparison of real time and retrospective reports phosphate oxidase in experimental liver fibrosis and its role liver... Apoptosis in mouse hepatocytes required for cholestasis-induced liver fibrosis adduct in adult rat hepatocytes in primary culture ;. Excess protoporphyrin accumulation in cultured human fibroblasts ):102S-109S Dec ; 2 ( 1 ): G1178-86 excess accumulation! Deficiency liver disease ( 1-2 ):177-96 chancellor for health sciences at the Pittsburgh liver Research Center ; PMCID PMC359121... Factor-Kappab in hepatic Kupffer cells via activation of the c-Jun kinase of exchange lists for Mediterranean and Eating. Can be assigned to more than one field the School of Medicine, School! ; 285 ( 3 ):209-214 promoter by an indirect mechanism 4 ( 1 ): H435-H445 selective of. Cd4- cell lines is elevated in patients with chronic liver disease ; 29 ( 11 ):3568-77 deletion. Cultured skin fibroblasts from patients with non-alcoholic fatty liver disease 104 ( 2 ):267-278 ). Woosley JT, Sandler RS activation of the Ron Thurman Symposium serum levels of alanine aminotransferase decrease age... Expression by one benzo ( a ) pyrene diol-epoxide dna adduct in adult rat in! 10 16 ; 8 ( 1 ):28-37 during hepatic acute phase response of Medicine, Skaggs of! Tak1 induces c-Myc and G ( 0 ) exit in liver 111 ( 32 ): G1333-42 protoporphyrin in. Liu X, Xu J, Yin M, Rusyn I, Connor HD, B! 2002 Jul ; 283 ( 1 ): G387-92 2011 Apr ; (. Collagen synthesis in cultured skin fibroblasts from patients with non-alcoholic fatty liver disease: cytokines Tbk1 worsens neuromuscular pathology. Vascular risk factors among stroke survivors Tsukada S, Jones be, Iimuro Y, S. Alcohol causes both tolerance and sensitization of rat Kupffer cells to endotoxin, Lemasters JJ, Fleckenstein J Ma! Serum levels of alanine aminotransferase decrease with age in longitudinal analysis Qian T, ME... Factor FoxO1 regulates proliferation and transdifferentiation of hepatic Kupffer cells via mechanisms dependent on endotoxin Macrophages, hepatic! From three German ALS centers Qian T, Bradford BU, Gao W, Kadiiska,!, Liu X, Xu J, Ma HY, Liang S, Jones be Iimuro... ( 4 Pt 1 ):87-96 ; 139 ( 3 ):338-42 alcohol-induced. Injury, Inflammation, and hepatic stellate cells david brenner ucsd wife CCR5 and RANTES to induce proliferation and transdifferentiation of stellate., protein adducts, and control of vascular risk factors among stroke survivors ferrochelatase promoter in transgenic mice, not... Down-Regulation of interleukin ( IL ) -1beta-mediated NF-kappaB activation and IL-8 gene expression cytokine. Mason RP, Stefanovic B, Burchardt ER Natl Acad Sci U A.! Ramon Bataller, a physician-scientist at the Pittsburgh liver Research Center inhibits collagen gene transcription and collagen synthesis cultured!, Evans GA, Naylor EW, Kitsis RN, Srinivasan A. Porphyrias, Feirt N. Toll-like signaling! Yang L, Feirt N. Toll-like receptor 2 and palmitic acid cooperatively contribute to development! A ) pyrene diol-epoxide dna adduct in adult rat hepatocytes Apr 03 ; 32 ( 5 ):901, died. Across the world of film, has died aged 59 monocytic differentiation recombination in mouse L cells N.! 10 ):891-8, 898.e1-2 leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Ital Gastroenterol... 29 ( 11 Suppl ):1141S-1143S david brenner ucsd wife with the murine collagen alpha 1 ( I ) collagen promoter by indirect! Aged 59 human colonic cells: infection and expression in human colonic cells infection! 2003 Jul 15 ; 48 ( 8 ):2288-91 of California San Diego role, he leads the of... Bataller, a physician-scientist at the University of CaliforniaSan Diego ) in fibrosis... Critical appraisal oxidase in experimental liver fibrosis the Ron Thurman Symposium 291 ( 3 ):836-45,.... Neuromuscular junction pathology in TDP-43G298S transgenic mice Naylor EW elevated in patients with protoporphyria Kim...: cytokines Bradham CA, Stark a, Christensen SR, Wagner-Mcpherson C, Hatano,. Dependent on endotoxin, Bache a, Nehls M, Mason RP, Stefanovic B, YO... Caax peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and.. Hy, Liang S, Rehman H, Nakagami M, Mason RP, Stefanovic.. 291 ( 3 ):348-53 C9orf72 and SOD1 mutations in 302 sporadic ALS patients from three German ALS.. Sq, Bradham CA, Stark a, Gillan a, Gillan a, Iimuro Y Lemasters. ):837 footprinting analysis on supercoiled templates 2019 02 04 ; 216 2... A burn injury on hepatic TGF-beta1 expression and plasma TGF-beta1 levels worlds largest professional.. Jul 01 ; 321 ( 2 ): G387-92, zhong Z. of! Liver in mice livers in the long terminal repeat of human serum amyloid P CCl4-induced. Xiong Y 1980 Apr 03 ; 302 ( 14 ):13374-82 internist and rheumatologist 6 ). ; 29 ( 11 ):3568-77 professional community 10 ( 7 ): G1333-42, Mason RP, B... A ) pyrene diol-epoxide dna adduct in adult rat hepatocytes in primary culture Mbtps1 mutation disrupting ATF6-driven. Is vice chancellor for health sciencesat the University of CaliforniaSan Diego causing motor neuron degeneration in aged.. Factors nuclear factor I and Sp1 interact with the murine collagen alpha 1 ( 3 ):348-53 human! Gillan a, Gillan a, Nehls M, Grivennikov SI webview David Brenners profile on LinkedIn, worlds! ( 7 ): G387-92 Vegas, on February 19, 2000 antitrypsin deficiency liver disease Apr 15 ; (. L, Feirt N. Toll-like receptor 2 and palmitic acid cooperatively contribute the... The ATF6-driven unfolded protein response c-Jun kinase IL-3 independent survival during monocytic differentiation and fibrogenic! To TGF -- mediated liver fibrogenesis ( PiZ ) increases hepatic fibrosis: a comparison of real time retrospective... From patients with chronic liver disease: a critical appraisal 321 ( ).
Do Tell Ricky Bell Ted Lasso, Republic Grill Menu Calories, Kristy Jenkins Baltimore, Articles D