Diarrhea is a common side effect of Zetia. Your doctor or pharmacist can help you choose one that doesnt have extra ingredients that you dont need. You should always consult your doctor or another healthcare professional before taking any medication. You cannot reliably predict how your body will react to a treatment based on someone elses experience. 22% in people who used Zetia with fenofibrate, 20% in people who used Zetia with fenofibrate, people who used Zetia with atorvastatin or simvastatin had their LDL levels reduced by an average of 21% to 27% (the percentage varied depending on the dosage used), people who used atorvastatin or simvastatin alone had their LDL levels reduced by an average of 7%, people who used Zetia had their sitosterol levels decreased by an average of 21% and their campstrol levels decreased by an average of 24%, people who used a placebo had their sitosterol levels decreased by an average of 4% and their campstrol levels decreased by an average of 3%, bile acid sequestrants, such as cholestyramine (Prevalite, Questran), colesevelam (Welchol), and colestipol (Colestid), statins, such as atorvastatin (Lipitor), rosuvastatin (Crestor), and simvastatin (Zocor), Both Zetia and Lipitor are FDA-approved to treat the following conditions* in adults when used with a. Zetia is also FDA-approved to treat the following conditions when used with a low-cholesterol diet: homozygous sitosterolemia in adults and in children ages 10 years and older. They are caused by deficiencies in enzymes involved in the synthesis of heme. Last medically reviewed on September 18, 2021. Merck, the manufacturer of Zetia, offers a Patient Assistance Program. Zetia is available in a strength of 10 milligrams (mg). Fenofibrate is a drug used to lower your triglyceride levels. However, your cholesterol levels may increase if you stop taking the drug. Below are medications that can interact with Zetia. Watch Part 2 here: https://youtu.be/HPfo2QOa89YHello Friends! These lists contain examples of serious side effects that can occur with Lipitor or with both drugs (when taken individually). Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Zetias side effects are usually mild, especially if youre taking Zetia alone. Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. What are the serious side effects of Zetia? The heart beats faster to pump it up to the brain, but with little success. Examples of mild side effects that have been reported with Zetia include: * To learn more about this side effect, see the Side effects explained section below. Sometimes brain zaps are also accompanied by dizziness, pain, or tinnitus, a ringing in the ears. What causes POTS? Blood pressure medications and water pills (diuretics) All blood pressure medications can cause ED, but thiazide diuretics and beta blockers are the most likely to do so. Yes, treatment with Zetia should lower your triglycerides. For example, in studies, some people had to stop taking the drug because their liver enzyme levels increased. Your doctor may stop your Zetia treatment if it isnt safe or effective for you. If you drink alcohol and have questions about drinking it during Zetia treatment, talk with your doctor. However, 0.3% of people who took Zetia alone experienced joint pain so bothersome that they had to stop treatment. These can be signs of rhabdomyolysis (muscle breakdown), which is a serious medical condition. This can raise your levels of these drugs and increase your risk of side effects. Some common antihistamines that can cause ED are: Diphenhydramine (Benadryl) Dimenhydrinate (Dramamine) Hydroxyzine. Both drugs are typically taken once each day. Common side effects may include: diarrhea; cold symptoms such as stuffy nose, sneezing, sore throat; pain in an arm or leg; joint pain; or. They may have suggestions depending on your weight and health goals. Note: Some of the drugs listed here are used off-label to treat these specific conditions. And your doctor can use this information to adjust your treatment plan if needed. However, side effects are generally mild and go away as the body adjusts to the medication. When taken together, it should be administered at least 2 hours before or 4 hours after a bile acid sequestrant. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. This means you should avoid foods that are high in cholesterol and other types of fat. Read more about these alternatives to traditional statin, Having high cholesterol puts you at risk for a heart attack or stroke. . The following information is provided for clinicians and other healthcare professionals. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Zetia is primarily cleared from the body through fecal excretion. The current stance of the Food and Drug Administration (FDA) is to avoid using expired medications. Allergic reaction. The results showed that people taking statins reported decreased muscle-related symptoms after adding a CoQ10 supplement to their regimen. Zetia is available in a generic form called ezetimibe. LDL cholesterol was reduced by 15% more in children who took Zetia and simvastatin than in children who took simvastatin alone. If you have joint pain while taking Zetia, you may also experience swelling, redness, or weakness in your joints. 2005-2023 Healthline Media a Red Ventures Company. Zetia is also used to reduce blood levels of fats called plant sterols in people with homozygous sitosterolemia. POTS-related fatigue is physical in nature . Zetia may be used with statin drugs to treat the following conditions in adults: Statins are another class of medications used to lower cholesterol. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. (A class of medications is a group of drugs that work in a similar way.) However, if the side effects last longer than . Specifically, Zetia is used along with a low-cholesterol diet to treat: Zetia is approved to treat these conditions in certain situations. yellowing of your skin or the whites of your eyes, ahajournals.org/doi/10.1161/JAHA.118.009835, organon.com/product/usa/pi_circulars/z/zetia/zetia_pi.pdf, Alternatives to Statins for Lowering Cholesterol. Plant sterols are similar to cholesterol. However, your doctor will check your cholesterol levels about 4 weeks after you start treatment. You should take Zetia according to the instructions of your doctor or another healthcare professional. Taking Zetia with cholestyramine can decrease the amount of Zetia in your body. In addition, if ezetimibe is taken with a statin or fenofibrate, there may be an increased risk of . Nausea/Vomiting. (Mixed hyperlipidemia is also known as mixed high cholesterol.). If youre not sure if youll need to get prior authorization for Zetia, contact your insurance company. Taking Zetia with cyclosporine (a drug that suppresses your immune system) can raise the levels of both medications in your body. The primary symptom of OI is lightheadedness or fainting. However, its important that you dont stop taking Zetia without first talking with your doctor. Most of these side effects may go away within a few days or a couple of weeks. diarrhea*. People with this condition have high levels of LDL (bad) cholesterol, high levels of triglycerides, and low levels of HDL (good) cholesterol. For information on the effectiveness of Zetia, see the Zetia uses section below. Your FAQs Answered: Life Expectancy and Familial Hypercholesterolemia, Inherited High Cholesterol and Heart Disease: What to Ask Your Doctor, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, Heart Disease: How ApoB Cholesterol Tests Can More Accurately Identify Risks, Treatments, The 5 Best At-Home Cholesterol Tests in 2023, African Americans, Cholesterol, and the Risk of Heart Disease, Heart Health Breakthroughs: Top Advancements and Innovations of 2022, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your mouth, tongue, or throat, which can make it hard to breathe, what dose of drug you were taking when you had the side effect, how soon after starting that dose you had the side effect, what your symptoms were from the side effect, what other medications you were also taking, any other information you feel is important, taking other medications, especially high dose statin drugs. 6. When you get Zetia from the pharmacy, the pharmacist will add an expiration date to the label on the bottle. If you have high cholesterol with hypertension (high blood pressure) or diabetes, youll likely have to take other drugs with Zetia to treat these conditions. During Zetia treatment, your doctor will likely recommend blood tests. Clinical studies have shown Zetia to be effective for treating homozygous sitosterolemia when used alone. This is because fenofibrate is the only fibrate Zetia was studied with, so it isnt known whether Zetia and other fibrate drugs are safe to use together. You can use the study as a second opinion to make health care decisions. They may also check you for signs of muscle breakdown or kidney damage. For this purpose, Zetia may be used alone or with fenofibrate. Learn about the side effects it can cause and how to manage them. Then you can share this information with your doctor. About Postural orthostatic tachycardia syndrome. The list below includes factors to consider. Its not known how many adults and children experienced muscle pain in clinical studies of other conditions treated with Zetia and statin drugs. Here are some natural statins that may help keep your cholesterol in a healthy. They can both be taken with or without food. Lipitor ( atorvastatin) and Zetia ( ezetimibe) are used to lower cholesterol levels in the blood. They can give you tips on how to deal with any side effects that may be bothersome. Mild side effects of Zetia when taken with a statin (another kind of cholesterol -lowering drug) may include: infection, such as a respiratory . Zetia can cause mild or serious side effects. Over time, plant sterols can build up in your blood vessels and raise your risk of heart disease. If youve had an allergic reaction to Zetia or any of its ingredients, you should not take Zetia. Bock's fainting spells are one of the hallmarks of POTS. No, hair loss isnt a known side effect of Zetia. Zetia reduces the buildup of fats, cholesterol, and other substances on the artery walls (this process is known as atherosclerosis) and if taken long term it may reduce the risk of heart disease. Sharing this information can help you avoid potential interactions. Zetia isnt known to interact with grapefruit or any other foods. Is it harmful to take a coenzyme Q10 (CoQ10) supplement along with Zetia to help prevent muscle-related side effects? Off-label use is when a drug thats approved to treat one condition is used to treat a different condition. trouble in swallowing. These lists dont include all possible side effects. Statins are drugs used to lower cholesterol. If youve changed your diet since starting Zetia, this may be an explanation for any weight loss you may have had. Different interactions can cause different effects. Zetia is metabolized in the small intestine and liver. Zetia is a brand-name prescription drug. You can also call the American Association of Poison Control Centers at 800-222-1222 or use their online tool. Zetia is FDA-approved to treat mixed high cholesterol when used with fenofibrate. At the end of the study, researchers found that: Mixed hyperlipidemia is a genetic condition caused by a mutation (change) in the genes that control how cholesterol and fats are cleared from your body. Taking Zetia with a statin may cause this side effect. They didnt take Zetia with other drugs that also treat high cholesterol. For more information on the possible side effects of Zetia, talk with your doctor or pharmacist. Its FDA-approved to treat certain forms of high cholesterol in adults and in children ages 10 years and older. For more information on these side effects, see Side effect details below. Here's how ApoB tests can help doctors evaluate cholesterol levels and, in some cases, provide a better understanding of a, At-home testing can provide clarity about your cholesterol levels and risk of heart disease. A malfunctioning ANS is sometimes called 'dysautonomia'. So stopping Zetia may lead to an increase in your cholesterol levels. It belongs to a class of drugs called cholesterol absorption inhibitors. But reviews and complaints about medications, including Zetia, may not be as reliable as other types of consumer reviews. Using Zetia with medications in the fibrate drug class raises your risk of gallstones even more. Ezetimibe may be used alone or with other drugs (such as "statins" or . Here is a list of conditions that the Food and Drug Administration (FDA) has approved Zetia and Crestor to treat. Energy Drinks, such as Red Bull, should be avoided in those with POTS. Talk with your doctor about birth control options that may be best for you. We avoid using tertiary references. The phase IV clinical study analyzes which people take Zetia and have Constipation. Avoid storing this medication in areas where it could get damp or wet, such as bathrooms. A generic drug is an exact copy of the active drug in a brand-name medication. All rights reserved. This is because large meals can cause blood to pool excessively in the abdomen. However, you shouldnt stop taking Zetia without first talking with your doctor. The following lists contain some of the key side effects that may occur while taking Zetia. Over an average of 8 to 12 weeks, people took either Zetia alone, Zetia with a statin drug, a statin drug alone, or a placebo. The following information describes dosages that are commonly used or recommended. Taking Zetia with a statin drug may increase your risk of developing some mild or serious side effects. If your doctor has prescribed Zetia and youre interested in using ezetimibe instead, talk with your doctor. * This is a partial list of mild side effects from Zetia. Sometimes doctors will recommend taking both a statin medication and Zetia for high cholesterol. Learn how we can help. Zetia can cause muscle-related side effects. For more information, see the Precautions section below. This active drug is also available as a generic medication. You may not have any symptoms of gallstones unless they cause your gallbladder to swell. This may be caused by genetics, smoking, not getting enough physical activity, or eating too many foods that are high in cholesterol. It is created by eHealthMe based on reports of 45,364 people who have side effects when taking Zetia from the FDA, and is updated regularly. Both Zetia and Crestor come as tablets that are swallowed. A large review by the American Heart Association compared studies of CoQ10. Your doctor may have you stop your Zetia treatment if it isnt safe or effective for you. Zetia may not be right for you if you have certain medical conditions or other factors that affect your health. If youre sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while youre using Zetia. Before trying something new, its common to look for written reviews about the experiences of others. * Sex and gender exist on spectrums. But its possible that some side effects may continue to affect you for as long as youre taking the medication. Talk with your doctor if you experience diarrhea while taking this medication. Read More. In studies, some people had to stop taking Zetia because of this side effect. But new medications can help lower cholesterol and improve heart health. Off-label use is when a drug thats approved to treat one condition is used to treat a different condition. The symptoms develop immediately and include dizziness and an intense headache. If you develop bothersome muscle pain or other muscle-related symptoms, talk with your doctor. It isnt known how often this side effect occurred with Zetia in clinical studies. For more information on these side effects, see Side effect details below. There arent any foods that have been specifically reported to interact with Zetia. shaking and sweating. People with this condition have high levels of plant sterols. People with this condition have high levels of LDL (bad) cholesterol. If you have a history of heavy alcohol use and are taking Zetia with a statin drug, you may have a higher risk of side effects. Tell them about all prescription, over-the-counter, and other drugs you take. This drug has not been studied in pregnant females.*. Most patients will need at least 64 to 80 ounces (8 to 10 cups) of hydrating liquids throughout the day, such as water, broth, juice, or decaffeinated tea. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. In certain conditions (such as when traveling), you may temporarily store Zetia at temperatures of 59F to 86F (15C to 30C). It can develop suddenly or maybe over time. Its intestinal molecular target is the Niemann-Pick C1-Like 1 (NPC1L1) sterol transporter. sinusitis. This can increase your risk of side effects from either medication. Postural orthostatic tachycardia syndrome (POTS) is one of a group of disorders that have orthostatic intolerance (OI) as their primary symptom. Cholesterol is made naturally in your liver. The expiration date helps guarantee that the medication is effective during this time. But it may be a sign that your liver isnt working as well as it should. Youll likely take it once a day. Postural orthostatic tachycardia syndrome (POTS) is a form of dysautonomia that is estimated to impact between 1,000,000 and 3,000,000 Americans, and millions more around the world. POTS is an unusual condition in which your heart rate speeds up by 30 or more beats per minute with little or no change in blood pressure. This is especially helpful to do when you first start taking new drugs or using a combination of treatments. Zetia is meant to be used in combination with a diet thats low in saturated fat and cholesterol. Phase IV trials are used to detect adverse drug . Fatigue. Some people witness mild symptoms, some have a big impact on their lives due . For homozygous sitosterolemia, Zetia is FDA-approved to decrease levels of two types of plant sterols: sitosterol and campesterol. If you and your doctor decide that Zetia treatment isnt right for you, you simply wont take any more doses. These lists contain up to 10 of the most common mild side effects that can occur with Zetia, with Crestor, or with both drugs (when taken individually). Cholesterol itself isnt a harmful substance. The actual price youll pay for any of these drugs depends on your treatment plan, your insurance plan, your location, and the pharmacy you use. Welchol is a prescription drug used to treat type 2 diabetes and high cholesterol. . Talk with your doctor if youre concerned about your risk of memory loss while using Zetia alone or with a statin drug. To reduce your symptoms in . If your cholesterol levels havent started to improve, they may recommend a different treatment for you. Muscle problems are common side effects of statin drugs. Clinical studies for ezetimibe did not note any difference in weight in those that took the drug versus those that did not. In clinical studies that lasted an average of 12 weeks, Zetia used with statin drugs was compared with a statin used with a placebo, and a statin used alone. But its not clear whether this side effect occurred in studies. However, Zetia shouldnt be used with fibrate drugs other than fenofibrate. Your doctor will likely start you on the typical dosage approved to treat your condition. Its not known if Zetia is safe to take during pregnancy. Eating large meals can worsen hypotension in some individuals with dysautonomia (Mathias, 2000). The actual price youll pay depends on your insurance plan, your location, and the pharmacy you use. Clinical studies have shown Zetia to be effective for treating primary high cholesterol when used alone or with statin drugs. Cardiology 33 years experience. POTS is a form of orthostatic intolerance that is associated with the presence of excessive tachycardia and many other symptoms upon standing. Some people with POTS also may have one or more . Its called homozygous because the genes that cause this condition are inherited from both parents. In Zetia's clinical studies, these were some of the side effects that occurred more often: pain in the arms or legs. Your side effect notes can include things such as: Keeping notes and sharing them with your doctor will help your doctor learn more about how Zetia affects you. You should always consult your doctor or another healthcare professional before taking any medication. More common side effects in people taking Zetia* include: * In studies, these side effects were reported in people who took Zetia by itself. For more information about the effectiveness of Zetia for lowering your triglycerides, see the Zetia uses section above. Instead, it belongs to a class of drugs called cholesterol absorption inhibitors. (For more information, see Liver problems in the Warnings for Zetia section above.). Dizziness is a rare side effect of taking Zetia. Tramadol will usually cause a blistering type rash with itching which you do not describe. For more information and to find out if youre eligible for support, call 800-727-5400 or visit the program website. For mixed high cholesterol, Zetia is FDA-approved to decrease levels of: For this purpose, Zetia is used with a low-cholesterol diet and is taken with other drugs. Clinical studies have shown Zetia to be effective for treating homozygous familial hypercholesterolemia when used with atorvastatin or simvastatin. This can cause gallstones (hardened stones in your gallbladder). However, animal studies dont always predict what will happen in humans. Get answers to some frequently asked questions about Zetias side effects. The Benary's Giants have large, double blossoms, 4 to 6 inches across, available in a rainbow of . More research is needed to know for sure. How long a medication remains good can depend on many factors, including how and where you store the medication. Others may experience GI issues in conjunction with other symptoms, such as fainting. * Zetia is also approved to treat these conditions in children ages 10 years and older. Yes, there are a few. A life-changing condition called POTS, which can cause fainting, irregular heartbeats and dizziness, particularly among young women, appears to be on the rise as a result of the coronavirus pandemic. These problems can include muscle pain and muscle weakness, and rarely, muscle breakdown. If you use Zetia and warfarin together, your doctor may want to monitor you more closely during your treatment. Statins shouldnt be used during pregnancy. It only comes in a strength of 10 milligrams (mg). New evidence shows that the drug makers Merck and Schering-Plough have conducted several studies of their popular cholesterol medicine Zetia that raise questions about its risks to the liver, but . You may also want to check out the online communities at Bezzy. Statins are commonly prescribed with Zetia to treat certain types of high cholesterol. What foods should I avoid while taking Zetia. Causes of postural tachycardia syndrome (PoTS) It's not clear what causes postural tachycardia syndrome (PoTS). These conditions can raise your risk of muscle problems while taking Zetia. Your doctor may prescribe Zetia with a statin drug. But the condition isn't well understood, and many patients are dismissed as having anxiety, delaying diagnosis. POTS is defined by its particular symptoms and an excessive increase in heart rate upon standing. Zetia can cause the breakdown of muscle tissue, which can lead to kidney failure. These symptoms could be life threatening and require immediate medical care. 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