I have my 14 week old pup simparica (vet recommended) 2 days ago. All antiparasitics for dogs lower the seizure threshold. That sh-t should be banned. Especially, Camelia who lost her furbaby because of a seizure that was apparently brought on by this medication. Another call to vet asking for an appt - seems like an an emergency now? Hoping we dont have any more issues and will not be giving this again. His temp was high and white blood cells elevated. I PRAY that our baby is okay with this second dose. I sure hope we don't have ongoing problems. I am starting to get scared they are both 80 lbs and the other dog is. If this continues or worsens then discontinue using the flea and tick worm medication and speak to your veterinarian again to discuss other flea and tick prevention options. Hoping for a good outcome!!! As a Followup. If most side effects are mild, ( vomiting 12 hours later could be due to other things the dog has eaten within those 12 hours), I am ok with that. Is due for another tablet but I have been holding off. She uses drops 4 times a year on the top of the neck for fleas etc and told me to address the heart worm problem with the vet. Then things got progressively worse. I had to give him flea prevention because he goes to Daycare. By June 7th, she had a rash over most of her body, itching and biting herself to bloody raw spots. They got him to eat a little the next morning and sent him home. My dog died from it after one dose within 24 hours. I dont like the idea if ingestible medicine that kills fleas. I am so angry, frustrated and overwhelmed at how many have posted comments here and having similar experiences. I take her everywhere as I'm terrified of it happening and her dying, we were convinced she was dying. First dose was on 4/1 and 9 days later he was vomiting goop (yellow thick goo), he would drink water and vomit. He had ONE dose that evening and completely lost his appetite within a couple days. She never did that before! Naturally, I want to make sure that she never has to go through that again. I am interested in the petition and the company's response. I honestly think she had a reaction to the medication. Vet did all kinds of tests but said it couldnt be simparica. Ticks are horrible here in Maine. Prednisone helped symptoms in our case but the seizures kept going even after stopping this horrible med. Vet suggested that I switch to Simparica Trio (he gets a kickback from the manufacturer). Got home 4 hours later and my dog fell down three times and is now seizing mainly her head . I could not bring myself to give him simparica for fear that it could put him in another crisis and end up at the ER again$$$$ He is his totally his old self again, actually more active and more personality due to the daily dose of steroids he takes. MONEY!!. Now that Ive read all these comments I think he has developed these issues because of this trio medication. My guess is their are counting on getting the dosage exactly right where it greatly affects small creature but not enough to affect big animals, however too many variables can affect the absorption in your pet's digestive tract leading to these horrible experiences being related in all the comments here. and now i'm on an hour by hour let's see if she will perk up. (My first warning sign right there). This seemed like perfect treatment 3 in 1 but at what cost? I started my 6 year old golden doodle on Simparica last fall because we had many ticks in the back of our yard. The exact same thing is happening to my dog now. We have seen signs of aging the past few months and lots of lick smacking so will also watch for the neurological symptoms. He has horrible water like stools. A dog fence is an important detail to consider when adopting a pet for the first time or moving your dog to a new home. Now Im scared ive been giving him Simparica Trio and it could be the cause of his progressively worsening sickness. Company asked us to do diagnostic testing at vet. His motor skills have been affected and hes been losing weight even though he eats heartily. Weighing your dog regularly will ensure that you are using the correct product size. The vet said the simparica didn't cause the disease but it could have been the link that pushed him into the Crisis. #JusticeforCassie My thoughts and prayers are with you all as I go through the same thing with my beautiful Cassie girl. Hi, Im having similar issues. And now I'm upset with myself for giving this to my dog without doing research. She is lethargic, unsteady on her feet, doesnt bark at all, showing signs of dimentia. The initial trial had seizure results but supposedly only in dogs with seizure history. Also vets needs to tell the truth!!! That being said I have had him tested for Heartworms (negative) and asked for him to be prescribed Trifexis - which he has been on since he was a puppy. This is happening now and she is still nowhere near 100% but I am hopeful that she will eventually fully recover. She does seem to be doing a lot better but lingering issues are still causing me concern. My 14 year old, 3.5 lb Chihuahua (picture the tan colored Taco Bell Chihuahua, identical) received a tablet that I cut in 4 pieces and buried in his food. I will be changing clinics immediately. I am so upset - I gave it to him last week and he had an accident in the house. I gave my morkie poo simparica trio from age 4 months until age 1 on advice of his vet. My 10 year old Standard Poodle had one dose of Simparica and had seizures two weeks later, which was yesterday. It's been the worst 2 months. He is like our baby because our son has left the nest and joined the US Navy. Although he didnt continue throwing up and was fine otherwise, he was still outside 12 hours later eating grass. I thought maybe it was just a allergy break out which she's never had this long now I'm wondering if she's continuing to have a reaction. . Gave my 3 year old Yorkie Simparica and 24hrs later he became hyperactive panting pacing and started hiding in dark places. I called the vet and am putting him back on Heartgard and Nexgard. How can it not be the Simparica that did this to my baby when nothing else changed. Each medication combats different pests. That was when I lived in Fort Lauderdale. If she comes out of this I will return to heartworm pills and topical flea and tick meds. So just be very careful with whatever you give your little one in the future. With the March 1 dose, on that day, I noticed him seeming to be very fearful and flinching on several occasions. Shes not the carefree setter she was prior to this medication. I would find another vet for a second opinion. Before sharing sensitive information, make sure you're on a federal government site. Anyway, he prescribed him pain relief for 7 days. It seems to be clearing up with Rx eye drops. I never saw a flea because he has a very thick coat. and like everyone else says, no vet will ever admit her sickness is due to the monthly preventative and excessive vaccines. Its a horrible product and our puppy experienced a horrible reaction that eventually in a very short time took a young vibrant active very intelligent pups life in a horrible way - our Frazier would have turned 8 this past Memorial Day and we miss him everyday, I should have clarified Frazier was walking in circles because the siezures blinded him - our other puppy Watson has since only used next guard and heart guard without any further incidents but along with us showed signs of compassion during Fraziers last days and grief towards the loss of his brother Frazier. I feel like this drug was pushed by my vet tech and veterinarian. After about 35 days he was back to normal. Needless to say, we will no longer be giving this to our lab or our other dog. He looked like he was having a seizure. I'm so sorry. Our vet gave us this medication for our 8 week old Great Dane puppy. My dog is on a "health care plan" with my vet. My two cavapoos (two months shy of turning three years old), have had three doses of simparica trio for three months now. I did and they said they are going to report it to the FDA. I thought the first one it happened to may have gotten something in her eye but then a few days later the other had the same issue. Side effects of Simparica Let us now look at possible side effects when administering Simparica. The FDA considers this level to be "very rare". Hoping that these side effects dont get worse and subside soon . . He had full wellness exam three ago and was in perfect shape. Thank you for this information. Youre an idiot then! Simparica Trio is a veterinary medicine used to treat dogs with flea or tick infestations and roundworm or hookworm infections in the gut. Called his vet and they gave no information. We did a cortisone pack to help him manage his "arthritis" symptoms that I totally feel were related to the simparica. He is 5 months old. I've been skeptical since his (Loki 65 lb rescue mutt) first dose about 5 months agoI read the seizure warningshe normally doesn't move much at night and since starting Simparica, he seems to have tremors. Hi there, So sorry to hear about your dog. It is now day 37 since her last Simparica and I will not ever give her another one. My dog is 9 yrs old . He has been on just Simparica with no problems. She still has her appetite at the moment. She probabpy had some in her system (which is quite common, even for well-cated-for puppies), which would explain her diarrhea. I keep praying she will recover and I feel so guilty for giving it to her. It started working on him right away, Diarrhea. Do you have a homeopathic vet in your area? This excerpt is from the healthline website and in reference to humans "GABA is considered an inhibitory neurotransmitter because it blocks, or inhibits, certain brain signals and decreases activity in your nervous system. I dont like that my dog looks at me like he doesnt know who I am. My baby is so sick from this Drug. The FDA is alerting pet owners and veterinarians of the potential for neurologic adverse events in dogs and cats when treated with drugs that are in the isoxazoline class. He was in excellent health prior to this incident. Vet said "cant be Simparica because he had 9 days ago". After 9 days he began vomitting, even water, and mouth chattering like he was scared. Manufactured by Zoetis, Simparica Trio contains three drugs: sarolaner, moxidectin, and pyrantel pamoate. 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